中国寄生虫学与寄生虫病杂志 ›› 1999, Vol. 17 ›› Issue (1): 9-34.

• 论著 • 上一篇    下一篇

海南省乐东县恶性疟原虫对氯喹抗性的变化

刘德全1,蔡贤铮2,任道性1,刘瑞君1,林世干2,曾林海2,唐铣 2
  

  1. 1 中国预防医学科学院寄生虫病研究所 上海 2000252 海南省热带病防治研究所 海口 570203
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1999-02-28 发布日期:1999-02-28

CHANGES IN CHLOROQUINE RESISTANCE OF PLASMODIUM FALCIPARUM IN HAINAN PROVINCE 

LIU Dequan 1;CAI Xianzheng 2;REN Daoxing 1;LIU Ruijun 1;LIN Shigan 2;ZENG Linhai 2;TANG Xian 2   

  1. 1 Institute of Parasitic Diseases;Chinese Academy of Preventive Medicine;shanghai 200025 2 Hainan Provincial Institute of Tropical Diseases, Haikou 570203
  • Received:1900-01-01 Revised:1900-01-01 Online:1999-02-28 Published:1999-02-28

摘要:   目的:监测海南省停用氯喹后抗氯喹恶性疟原虫对氯喹抗性的消长。方法:选择恶性疟原虫对氯喹有高度抗性且恶性疟发病率较高的海南省乐东县为观察点,采用WHO标准体外微量法和体内四周法,间隔一定时间检测一次。结果:停用氯喹18年,体外法,抗性率由1981年的97.9%下降至1997年的26.7%(P<0.001),完全抑制裂殖体形成的平均药浓度由10.46±7.14pmol/μl血降至1.63±1.47pmol/μl血(P<0.001);体内法,抗性率由1981年的84.2%降为1997年的18.4%(P<0.001),RⅢ占抗性病例的比例由53.1%降为14.3%。结论:海南省停用氯喹后恶性疟原虫对氯喹逐渐恢复了敏感性

关键词: 恶性疟原虫, 抗药性, 敏感性, 氯喹

Abstract:  AIM:To observe the variation in resistance of Plasmodium falciparum after the cessation of chloroquine medication. METHODS:WHO standard in vitro microtest and in vivo test were used. RESULTS: In vitro test showed that the rate of chloroquine resistant P.falciparum dropped from 97.9% in 1981 to 26.7% in 1997 ( P<0.001). The mean concentration of chloroquine for complete inhibition of schizont formation declined from 10.46±7.14 pmol/ul blood in 1981 to 1.63±1.47 pmol/μl blood in 1997( P<0.001). In vivo test showed that the rate of chloroquine resistant P.falciparum decreased from 84.2% in 1981 to 18.4% in 1997 (P<0.001) . The proportion of RⅢ cases to the total resistant cases dropped from 53.1% in 1981 to 14.3% in 1997. CONCLUSION:A tendency of progressive decline of resistance of the parasite was revealed after the cessation of chloroquine medication.

Key words: Plasmodium falciparum, resistance, sensitivity, chloroquine.