实验感染人肉孢子虫的临床症状及排孢子囊观察

中国寄生虫学与寄生虫病杂志 ›› 1999, Vol. 17 ›› Issue (1): 7-27.

实验感染人肉孢子虫的临床症状及排孢子囊观察

陈新文1　左仰贤1　左薇薇2

1　云南大学生物系　昆明　6500912　昆明医学院第一附属医院检验科　昆明　650031

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1999-02-28 发布日期:1999-02-28

OBSERVATION ON THE CL INICAL SYM PTOM S ANDSPOROCYST EXCRETION IN HUMAN VOLUNTEERSEXPERIM ENTALLY INFECTED W ITH SARCOCYSTIS HOM IN IS

CHEN Xinwen¹, 　ZUO Yangxian¹, 　ZUO Weiwei²

1　Biology Department of Yunnan University , Kunming 6500912　Department of Laboratory , First Affiliated Hospital of Kunming Medical College, Kunming 650031

Received:1900-01-01 Revised:1900-01-01 Online:1999-02-28 Published:1999-02-28

摘要/Abstract

摘要： 提要　目的: 观察人体感染人肉孢子虫(S arcocy stis hom inis) 的孢子囊排放情况和临床表现。方法: 志愿者通过生食含人肉孢子虫包囊的牛肉而感染。1名吞食自然感染的黄牛横纹肌内人肉孢子虫包囊约1 567个, 2名分别吞食实验感染的水牛肌肉中的人肉孢子虫包囊各约14 740个。用硫酸锌离心漂浮法逐日粪检。结果: 3名志愿者分别于感染后d11～ 40、d12～ 23和d10～ 30粪中排出成熟孢子囊和卵囊, 于d18、d14和d14达到排出高峰。并于感染后1 w k～ 4 w k出现腹痛、腹胀、腹泻和嗜酸性粒细胞增加。未经服药, 29 d 内自愈。结论: 人体感染人肉孢子虫后均出现消化道症状, 于d10～ 12粪中开始排出孢子囊和卵囊, 持续排出时间为11 d～ 29 d。

关键词: 人肉孢子虫　实验感染　孢子囊　临床症状　血象

Abstract: 　A IM: To investigate the excretion of sporocysts and clinicalm anifestations in humans experimentally infected of Sarcocystis hominis. METHODS: Three vo lunteers were infected by eating raw beef containing cysts of S.hominis. One ingested about 1567 cysts in skeletalmuscles of a naturally infected cattle; two volunteers each ingested about 14740 cysts from an experimentally infected water buffalomeat. Fecalex-amination by zinc sulfate flotation m ethod was conducted daily sinced4 post infection (pi). RESULTS: ree
spo rocyst s and oocysts were found in their faeces from d11～40, d12～ 23, d10～30 pi , and peaked at d18, d14, d14.All of them presented clinical symp toms such as abdominal pain, distension, watery diarrhea and eosinoph ilia 1 w k～4 wkpi and were spontaneou slycured with in 29 days piwithout taking any medicine.CONCLUSION: All the experime tally infected persons had gast rointest inal symptoms and passed sporo-cysts and oocysts in faeces 10～ 12 days after infection and persisted for 11～29 days.

Key words: Sarcocy stis hominis, experimental infection, sporocyst, clinical symptoms, 　hemogram

陈新文左仰贤左薇薇. 实验感染人肉孢子虫的临床症状及排孢子囊观察[J]. 中国寄生虫学与寄生虫病杂志, 1999, 17(1): 7-27.

CHENXinwen;ZUOYangxian;ZUOWeiwei. OBSERVATION ON THE CL INICAL SYM PTOM S ANDSPOROCYST EXCRETION IN HUMAN VOLUNTEERSEXPERIM ENTALLY INFECTED W ITH SARCOCYSTIS HOM IN IS[J]. Chinese Journal of Parasitology and Parasitic Diseases, 1999, 17(1): 7-27.