中国寄生虫学与寄生虫病杂志 ›› 1997, Vol. 15 ›› Issue (4): 212-215.

• 论著 • 上一篇    下一篇

湖沼型血吸虫病流行区用蒿甲醚预防感染日本血吸虫的现场研究

徐明生1; 肖树华2; 宋王寥1; 陶承国1; 夏长根1; 汪昊1; 陈名刚2; 郑江2; 卜存和3; 胡福延3; 欧能3; 章新升3   

  1. 1 安徽省血吸虫病防治研究所; 2 中国预防医学科学院寄生虫病研究所; 3 安徽省贵池市血吸虫病防治站
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1997-08-30 发布日期:1997-08-30

OBSERVATION ON THE EFFECT OF ARTEMETHER ON CONTROLLING SCHISTOSOMIASISJAPONICA IN AN ENDEMIC AREA OF MARSHLAND

Xu Mingsheng1; Xiao Shuhua2; Song Qiu1; Tao Chengguo1; Xia Changgen1; Wang Hao1;
Chen Minggang2; Zheng Jiang2; Bu Chinhe3; Hu Fuyan3; Ou Neng3; Zhang Xinsheng3   

  1. 1 Anhui Provincial Institute of Parasitic Disease Control and Research, Wuhu 241000 2 Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shang hai200025 3 Guichi Municipal Anti-schistosomiasis Station, Guichi 247100
  • Received:1900-01-01 Revised:1900-01-01 Online:1997-08-30 Published:1997-08-30

摘要: 目的 :观察湖沼型血吸虫病流行区用蒿甲醚预防日本血吸虫感染的效果。方法 :1996年4— 11月, 选择安徽省贵池市唐田乡 2个村为试点 ,选择 6岁— 65岁村民随机配对分为蒿甲醚组和对照组。在服蒿甲醚前 2 0 d,经粪检查病 ,并服单剂吡喹酮 4 0 mg/kg— 50 mg/kg治疗。于 5月下旬口服第 1剂蒿甲醚 6mg/kg, 以后每半个月服 1次 ,共 10次 ,对照组口服相同剂型的安慰剂。结果 :口服蒿甲醚 4 33例粪检全部阴性,无急性血吸虫病发生 ;对照组 4 52人的粪检感染率为8.9% ,并发生 1例急性血吸虫病。口服蒿甲醚对肝、肾功能、网织红细胞和心电图未见明显异常。结论 :在整个传播季节每半个月口服 1次蒿甲醚6 mg/kg, 对湖沼型重度血吸虫病流行区人群有较好的预防作用, 为制定防治湖区血吸虫病策略提供一种新的措施。

关键词: 血吸虫病, 预防, 蒿甲醚

Abstract: AIM:To study the prophylactic effectof artemether againstinfection caused by
Schistosoma japonicum,in an endemic area of marshlands.METHODS:From April to November, 1996,2 villages in Tangtian township of Guichi City,Anhui Province were selected as the pilot site.A
total of 920 villagers aged 6 - 6 5 years were selected as subjects and allocated randomly to
artemether group and the control group by pairing method.About 2 0 days before artemether
prevention stool examination was carried out for the villagers of both groups, which was followed by treatment of all the examinees with praziquantel at a single do e of 40- 50 mg/kg. In artemether group , an initial do se of 6mg/kg was given in the last ten-day period of May, pursued by repeated dosing once every 15 days for 10 times. Placebo (starch) 6 mg/kg was given to villagers in the control group simultaneously. The preventive efficacy was evaluated by stool examination 4 weeks after the last medication. RESULTS: In artemether group no egg positive case (0/433) was seen, while in the control group 40 villagers were revealed egg-positive with an infection rate of 8. 8% (40/452). Furthermore, 1 case of acute schistosomiasis was present in the control group , but none in artemether group. No apparent changes in hepatic and renal functions, reticulocyte count or electrocardiograph was evidenced after completion of artemether administrartion. CONCLUSION: In hyper-endemic area of schistosomiasis in marsh lands, artemether 6 mg/kg given orally once every 15 days to villagers throughout the whole transmission season resulted in promising protection, that the drug could prevent them from schistosome infection. The study provides an effective measure for planning new strategies to be used in schistosomsis control.

Key words: Schistosomiasis, prophylaxis, artemether