中国寄生虫学与寄生虫病杂志 ›› 1997, Vol. 15 ›› Issue (4): 208-211.

• 论著 • 上一篇    下一篇

口服蒿甲醚降低洲坝垸型血吸虫病流行区人群感染血吸虫的效果

田子英1; 肖树华2; 肖俊文1; 刘德山1; 周应彩1; 郑江2; 陈名刚2; 屈贵顺1; 张小云1; 姚孝明1; 张献忠1; 张德林3; 黄阁贤3   

  1. 1 湖南省常德市血吸虫病防治院; 2 中国预防医学科学院寄生虫病研究所; 3 湖南省常德市汉寿县血吸虫病防治办公室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1997-08-30 发布日期:1997-08-30

REDUCTION OF SCHISTOSOMA JAPONICUM INFECTION IN AN ENDEMIC AREA IN ISLET WITH EMBANKMENT AFTER PROPHYLAXISWITH ORAL ARTEMETHER THROUGHOUT THE TRANSMISSION SEASON

Tian Ziying1; Xiao Shuhua2; Xiao Junwen1; Zhou Yincai1; L iu Deshan1; Zheng
Jiang2; Chen Minggang2; Qu Guishun1; Zhang Xiaoyun1; Yao Xiaoming1; Zhang Xianzhong1; Zhang
Delin3; Wang Gexian3   

  1. 1 Changde Anti-schistosomiasis station, Changde City , Hunan Province, Changde 415000 2 Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai 200025 3 Office for Schistosomiasis Control of Hanshou County, Changde City , Hunan Province, Hanshou 415900
  • Received:1900-01-01 Revised:1900-01-01 Online:1997-08-30 Published:1997-08-30

摘要: 目的 :在洲垸型血吸虫病流行区 ,于传播季节观察经常接触疫水人群口服蒿甲醚预防感染血吸虫的效果。方法 :选择 5岁 - 60岁的村民 789人 ,随机配对分为蒿甲醚组 ( 395人 )和对照组 ( 394人 )。预防前 1个月 ,两组人群粪检 ,其血吸虫感染率各为 2 9.5%和 2 9.2 % ,随即用吡喹酮治疗 ,虫卵阳性者 1次顿服 50 mg/ kg,虫卵阴性者顿服 4 0 mg/ kg。蒿甲醚组人群于 6月上旬接触疫水半个月后口服第 1剂蒿甲醚6mg/ kg,以后每半个月服药 1次 ,共计 9次。对照组人群在上述时间内服安慰剂。两组人群于末次服药后 1个月作粪检 ,评价预防效果。结果 :蒿甲醚组和对照组完成 9次服药和作粪检的分别为 2 90人和 30 5人 ,虫卵阳性率则各为 1.7%和 2 6.9% ,两者间的差别具有显著意义。结论 :在洲垸型血吸虫病流行区 ,口服蒿甲醚可保护人群 ,防止重复感染 ,降低人群的血吸虫感染率。

关键词: 日本血吸虫, 预防血吸虫病, 血吸虫感染率, 蒿甲醚

Abstract: AIM:To study the prophylactic effect of oral artemether on protecting people from
Schistosoma japonicum infection in an endemic area located in an islet with embankment.
METHODS:789villagers aged 5 - 6 0 years were allocated randomly to artemether (Art) and the
control group by pairing method. The egg- positive rates in Art group and the control group were
comparable (2 9.5 % vs 2 9.2 % ) . The firstdose of artemether 6 mg/ kg was given in the first
ten- day of June to the villagers who had contacted the infested-water within 15 days, followed by repeated dosing once every 15 days for 9 times. The villagers in the control group were treated with placebo concurrently. Fecal examination was made for the 2 groups one month after the last medication for evaluation of preventive effect. RESULTS: In artemether group 5 out of 290 villagers who had completed 9 times of medication showed egg-positive with an infection rate of 1. 7% , while in the control group , 82 out of 305 were positive with an infection rate of 26. 9%. The difference between the 2 groups was statistically significant. CONCLUSION: The villagers in the schistosomiasis endemic area, an islet with embankment, were protected from superinfection of S. japonicum by administering artemether throughout the whole transmission season.

Key words: Schistosoma japonicum, prophylaxis of schistosomiasis, schistosomal infection rate, artemether