关键词: 日本血吸虫, 免疫核糖核酸, 佐剂, ELISA

Abstract: The adjuvant effect of schistosome iRNA on the schistosome antigen ws studied.The results by using ELISA showed that the antibody level in mice immunized with SiRNA+SWA was significantly higher than in those only immunized with SiRNA or SWA.After cercariae challenge infection,mice immunized with SiRNA+SWA or SiRNA had higher worm reduction rate.However,there were no significant differences between the two groups of mice on worm reduction rate,These results suggested that the host humoral response can be enhanced by SiRNA and that the host immunity against S.japonicum failed to be enhanced by SiRNA.