关键词: 日本血吸虫, 细胞因子, IL-, IFN-γ

Abstract: The capacity of mitogen Con A and SEA stimulated spleen cells to produce cytokines IFN γ and IL 2 was studied in S.japonicum infected mice every two weeks from o to 14 wk after infection. The results showed that the levels of these two cytokines began to rise at the 4th wk after infection and reached a peak level at 6 8 wk, then declined to the levels similar to those pre infection at 12 14 wk after infection. The IFN γ level reached the peak earlier than the IL 2 level. The dynamics of cytokine level in both mitogen and antigen stimulated group was similar. The results suggest that IL 2 and IFN γ might be the essential cytokines involved in egg granuloma formation in schistosomiasis japonica.