中国寄生虫学与寄生虫病杂志 ›› 1994, Vol. 12 ›› Issue (1): 56-59.

• • 上一篇    下一篇

联合化疗对人体内肠线虫卵作用的研究

杨维平,沈一平,邵靖鸥,董恺,章涛,胡玉兰,许聚岭   

  1. 扬州大学医学院; 南京医学院; 扬州市血吸虫病防治所; 江都县卫生防疫站
  • 出版日期:1994-02-28 发布日期:2017-01-06
  • 基金资助:
    江苏省自然科学基金

EFFECT OF COMBINED CHEMOTHERAPY AGAINST HUMAN INTESTINAL NEMATODE EGGS

  • Online:1994-02-28 Published:2017-01-06

摘要: 选用阿苯达唑300mg伍用复方甲苯达唑375mg1.5d联合疗法分别治疗蛔虫感染者7例、鞭虫感染者7例和钩虫感染者9例。治后3d内粪检蛔虫卵全部转阴,鞭虫卵和钩虫卵亦于治后5d内全部转阴。连续粪便培养发现,治后虫卵发育率较治前明显降低,治后2d对蛔虫、鞭虫和钩虫的杀卵率分别达98.8%、100%和100%。研究结果表明,联合化疗具较强的体内驱虫杀卵作用。

关键词: 阿苯达唑, 甲苯达唑, 化疗, 蛔虫病, 鞭虫病, 钩虫病

Abstract: The effect of a combination of albendazole and mebendazol was evaluated by stool exa mination in 7 patients with Ascaris lumbricoides eggs,7 patients with Trichuris trichiura eggs and 9 patients with hookworm eggs.Albendazole and mebendazole were given at 300 mg and 375 mg,respectively.Both drugs were divided into 3 parts, one part b.id., and given in 1.5 days.The fecal eggs turned negative in all the patients with Ascaris infection in 3 days,while the fecal eggs were negative in all patients with Trichuris or hookworm infection in 5 days.The development rates of the eggs were remarkably lower post treatment than pre treatment.It was found that the ovicidal rates in human ascariasis,trichuriasis and ancylostomiasis were 98.8% ,100% and 100%,respectively on the second day following the initiation of treatment.The results showed that the worm repelling and ovicidal effect of the combined chemotherapy was more evident.

中图分类号: