中国寄生虫学与寄生虫病杂志 ›› 1992, Vol. 10 ›› Issue (4): 241-244.

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停用氯喹12年抗氯喹恶性疟原虫对氯喹抗性的变化

刘德全,刘瑞君,任道性,高大庆,张春勇,邱持平,蔡贤铮,林翠芬,梁爱华,唐铣   

  1. 中国预队医学科学院寄生虫病研究所; 中国预队医学科学院寄生虫病研究所; 中国预队医学科学院寄生虫病研究所; 中国预队医学科学院寄生虫病研究所; 中国预队医学科学院寄生虫病研究所; 中国预队医学科学院寄生虫病研究所; 海南省热带病防治研究所; 海南省热带病防治研究所; 海南省热带病防治研究所; 海南省热带病防治研究所
  • 收稿日期:2017-01-07 修回日期:2017-01-07 出版日期:1992-11-30 发布日期:2017-01-09

ALTERNATION IN RESISTANCE OF PLASMODIUM FALCIPARUM TO CHLOROQUINE AFTER CESSATION OF CHLOROQUINE MEDICATION FOR TWELVE YEARS

  • Received:2017-01-07 Revised:2017-01-07 Online:1992-11-30 Published:2017-01-09

摘要: 由于海南省恶性疟原虫对氯喹普遍产生了抗性,所以于1979年开始,在全岛范围内停止使用氯喹防治恶性疟。为了了解停止使用氯喹后恶性疟原虫对氯喹抗性的消长情况,作者以该省乐东县为观察点,于1981—1991年间,每隔2—3年测定1次恶性疟原虫对氯喹的敏感性。结果发现,停止使用氯喹后,恶性疟原虫对氯喹的抗性呈逐渐降低趋势,体外法测得的抗性率由1981年的97.9%,降至1991年为60.9%(P0.001),完全抑制裂殖体形成的平均剂量由1981年的10.46pmol/μl,降至1991年的3.02pmol/μl(P0.001),需用大剂量(6.4pmol/μl)才能完全抑制裂殖体形成的病例比例,由1

关键词: 恶性疟原虫, 氯喹, 敏感性, 抗性, 监测体内四周法, 体外微量法

Abstract: In view of the fact the resistance of Plasmodium falciparum to chloroquine occurred extensively in Hainan,a decision was me.de in 1979 that the use of chloroquine should be quitted in the whole province.A longitudinal survey on chloroquine-sensitivity of P.falciparum was carried out during 1981-1991 to observe the variation in resistance of the parasite after the cessation of the chloroquine medication for every 2-3 years.A tendency of progressive decline of resistance was revealed.By using in vitor test,the rate of chioro-quine-resistant P.falciparum dropped from 97.9% in 1981 to 60.9% in 1991 (P0.001).The mean dosage of chloroquine for complete inhibition of schizont formation declined from 10.46pmol/μl in 1981 to 3.02 pmol/μl in 1991 (P0.001).The percentage of population requiring larger dosage (6.4pmol/μl to completely inhibit schizont formation declined from 83.3% in 1981 to 17.4% in 1991 (P0.001); whereas those requiring small dosage (1.6 pmol/μl),increased from 4.2% in 1981 to 60.8% in 1991 (P0.001).In in vivo test,the rate of chloroquine-resistant P.falciparum decreased from 84.2% in 1981 to 40% in 1991 (P0.001).The proportion of RⅡ plus RⅢ cases of the total resistant cases dropped from 59.4% in 1981 to 37.5% in 1991 (0.02P0.01).