关键词: 阿苯达唑, 复方甲苯达唑, 复方噻嘧啶, 噻嘧啶, 土源性线虫

Abstract: The efficacy of broad-spectrum anthelmintics in current use was studied in Hengshan County,Hunan Province.The vermicides under study include albendazole (400mg,single dose),mebendazole composite (mebendazole 100mg and levamizole 25mg bid×3d),oxantel pyrantel pamoate composite(pyrantel pamoate 150mg and oxcntel pamoate 150mg bid×2d),and pyrantel pamoate composite (base 10mg/kg,single dose).Therapeutic effect assessed 2 weeks after medication revealed Ascaris egg negative rates or cure rates (CR) of 97.5-100% for the former 3 regimens,and 80.9% for the latter one,while CR for hookworm infection were 95.4%,78.6-100%,96.7% and 83.3%,respectively.A follow-up survey pursued 4 weeks post treatment showed no significant difference in CR for the above regimens.Judging from CR in Trichuris trichiura infection,pyrantel pamoate composite was recommended as the drug of choice (89.3%),which was followed by mebendazole composite (64.6-83.8%) and albendazole (28.2-42.6%),whereas pyrantel pamoate was inefficacious.Obvious egg reduction rates were evidenced post application of the above drugs in trichuriasis treatment except pyrantel pamoate at single dose.