中国寄生虫学与寄生虫病杂志 ›› 1988, Vol. 6 ›› Issue (1): 26-28.

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青蒿醚与青蒿酯治疗疟疾的临床研究

王槐芳,石维志,冯通桂,张受凡,李培寿,甘俊,李国桥,郭兴伯   

  1. 广西寄生虫病防治研究所; 广西寄生虫病防治研究所; 广西寄生虫病防治研究所; 广西医学院; 广西医学院; 广西医学院; 广州中医学院; 广州中医学院
  • 收稿日期:2017-01-10 修回日期:2017-01-10 出版日期:1988-02-28 发布日期:2017-01-10

CLINICAL STUDY ON TREATMENT OF MALARIA WITH ARTEMETHER AND ARTESUNATE

  • Received:2017-01-10 Revised:2017-01-10 Online:1988-02-28 Published:2017-01-10

摘要: 用青蒿醚片剂及青蒿酯钠盐粉针剂,总剂量为160~800mg,治疗各种疟疾现症病人772例,临床治愈率100%。杀虫速度两药均较青蒿素等6种抗疟药快。青蒿酯钠针剂肌肉注射或静脉推注抢救凶险型疟疾25例,疗效满意,但1个月内两药的复燃率仍高达46.6%(304/652)。

关键词: 临床研究, 青蒿酯钠, 恶性疟, 疟疾防治, 间日疟, 静脉推注, 防治研究, 阴转时间, 寄生虫病, 凶险型疟疾

Abstract: As artemether and artesunate are both soluble in water, they are able to overcome the difficulty of preparation caused by the insolubility of artemisinine. Treatment of 772 cases of various forms of malaria at a total dose of 160-800mg yielded excellent effect with 100% recovery rate, the parasite clearance time being shorter than that of artemisininc and six other antimalarial drugs. In particular, when treating 25 severe cases of malaria, sodium artesunate injection led to satisfactory result, either intramuscularly or intravenously. It is the most effective new antimalarial drug. There were no side-effects, and no significant influences on the function of heart, liver, kidney and other important organs. However, the recrudescence rate of 46.6%(304/652) was relatively high.