中国寄生虫学与寄生虫病杂志 ›› 1984, Vol. 2 ›› Issue (3): 150-153.

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青少年血吸虫病性侏儒症患者的内分泌改变——附28例分析

何运钰,张立,刘英,陈惠云,陆仁康,李竞,张庆堂,闵传庆,徐志群   

  1. 皖南医学院附属医院; 皖南医学院附属医院; 皖南医学院附属医院; 皖南医学院附属医院; 皖南医学院附属医院; 皖南医学院附属医院; 安徽省青阳县人民医院; 安徽省青阳县人民医院; 青阳县血吸虫病防治站
  • 收稿日期:2017-01-12 修回日期:2017-01-12 出版日期:1984-08-31 发布日期:2017-01-12

ENDOCRINE CHANGES IN 28 YOUNG PATIENTS WITH SCHISTOSOMIASIS DWARFISM

  • Received:2017-01-12 Revised:2017-01-12 Online:1984-08-31 Published:2017-01-12

摘要: 本文报告28例青少年血吸虫病性侏儒症患者的内分泌改变。男性患者血浆睾酮、雌二醇浓度均显著低于对照值;女性患者血浆睾酮显著高于对照值,雌二醇低于对照值,但无统计学意义。患者的血清黄体生成素、甲状腺素。血浆皮质醇、生长激素浓度均在正常范围。促黄体素释放激素垂体兴奋试验,女性6例中有2例呈低差反应,男性7例中有5例反应异常。血吸虫病性侏儒症患者的骨生长与性发育障碍可能与失长介质素合成与分泌不足及性腺发育不良有关,并与垂体性侏儒症的内分泌功能状态有一定的差异。

关键词: 血吸虫病性, 内分泌改变, 侏儒症, 放射免疫测定, 生长介质, 兴奋试验, 骨生长, 男性患者, 肾上腺皮质, 女性患者

Abstract: Endocrine changes were determined in 28 young patients with schistosomiasis dwar-fism, including 15 girls and 13 boys, with an average age of 16.4 years. Testosterone and estradiol concentrations of male patients were significantly lower than the control values. Testosterone concentrations of female patients were significantly higher than the control values. Estradiol concentrations were lower than normal levels, without statistical significance. LH, F, T, GH concentrations in all patients were within normal limits. LH responses to LRH agonist analogs were abnormal in 2/6 of female patients and 5/7 of male patients. Insufficient synthesis and secretion of somatomedin is probabaly responsible for disturbances of bone and sex ual development. The endocrine function in schistosomiasis dwarfism is different to a certain extent from that in pituitary dwar-fism.