中国寄生虫学与寄生虫病杂志 ›› 2023, Vol. 41 ›› Issue (2): 223-227.doi: 10.12140/j.issn.1000-7423.2023.02.016

• 综述 • 上一篇    下一篇

多房棘球蚴病相关细胞信号通路的研究进展

马慧(), 种世桂, 陈根, 张伶慧, 秦俊梅, 赵玉敏*()   

  1. 桂林医学院基础医学院人体寄生虫学教研室,广西桂林 541199
  • 收稿日期:2022-05-11 修回日期:2022-06-21 出版日期:2023-04-19 发布日期:2023-04-19
  • 通讯作者: 赵玉敏
  • 作者简介:马慧(1995-),女,硕士研究生,从事寄生虫病防治研究。E-mail: mahuihui0405@163.com
  • 基金资助:
    广西自然科学基金面上项目(20191JA140480);国家自然科学基金地区项目(8196080417)

Research progress on the cellular signal pathways associated in alveolar echinococcosis

MA Hui(), CHONG Shigui, CHEN Gen, ZHANG Linghui, QIN Junmei, ZHAO Yumin*()   

  1. Department of Parasitology, School of Basic Medical Sciences, Guilin Medical University, Guilin 541199, Guangxi, China
  • Received:2022-05-11 Revised:2022-06-21 Online:2023-04-19 Published:2023-04-19
  • Contact: ZHAO Yumin
  • Supported by:
    Guangxi Natural Science Foundation(20191JA140480);National Natural Science Foundation of China(8196080417)

摘要:

多房棘球蚴病(AE)是一种在北半球高纬度地区流行、危害程度高的人兽共患寄生虫病。AE通常原发于肝组织,多房棘球蚴在患者体内呈浸润性生长,对累及脏器的形态及生理功能造成严重损伤。研究表明,多房棘球蚴及生发层细胞的增殖、机体免疫应答及免疫细胞的分化均与丝裂素原活化蛋白激酶(MAPK)、胰岛素(insulin,Ins)、程序性死亡受体-1(PD-1)、生长转化因子-β(TGF-β)等细胞信号通路有较为密切的联系。本文从相关细胞信号通路在多房棘球蚴病中对多房棘球蚴及宿主产生的免疫调节作一综述。

关键词: 多房棘球蚴病, 细胞信号通路, 免疫调节

Abstract:

Alveolar echinococcosis (AE) is a highly harmful zoonotic parasitic disease, which is prevalent in the high latitudes of the northern hemisphere. AE usually occurs in liver tissue and Echinococcus grows infiltratively in patients. It can cause serious damage to the morphology and physiological function of the involved organs. In this process, the cellular signaling pathway is closely related to the course of AE. Cell signaling pathways, such as the mitogen-activated protein kinases (MAPK) pathway, insulin (Ins) pathway, programmed cell death protein 1 (PD-1) pathway and transforming growth factor β (TGF-β) pathway, are closely related to proliferation of Echinococcus, body immune response and differentiation of immune cells. This article has reviewed the role of related cellular signaling pathways in the immune regulation of alveolar echinococcosis and host in the process of AE infection.

Key words: Alveolar echinococcosis, Cellular signaling pathway, Immune regulation

中图分类号: