蠕虫及其来源分子对螨性哮喘免疫调控的研究进展

doi:10.12140/j.issn.1000-7423.2023.02.001

摘要/Abstract

摘要：

随着人们生活卫生水平的提高，我国寄生蠕虫的感染率显著下降，逐渐进入后寄生虫时代。但是与此同时，螨性哮喘的发病率逐年上升，造成了重大的社会经济负担。越来越多的证据表明，蠕虫感染与过敏性疾病之间存在一定的联系。本文对蠕虫及其来源分子对螨性哮喘免疫调控的研究进行综述，包括对抗原递呈细胞、B细胞、T细胞的免疫应答和细胞因子释放的直接调节作用以及蠕虫通过肠道微生物菌群的间接调节作用，为螨性哮喘的治疗提供新的思路与方向。

关键词: 蠕虫, 蠕虫分子, 免疫调节, 螨性哮喘

Abstract:

With the improvement of living hygiene, the helminth infection rate has declined, and people have entered the post-parasite stage. But at the same time, the incidence rate of mite-induced asthma is increasing, which has caused a significant social and economic burden. Increasing evidence showed a correlation between helminth infection and allergy. This article reviews the regulation of helminth and their derived molecules on the occurrence and development of mite-induced asthma, including the direct regulation of antigen-presenting cells, humoral immunity, cellular immunity, release and action of cytokines, and the indirect regulation by regulating intestinal microflora, providing new ideas and directions for the treatment of mites-induced asthma.

Key words: Helminth, Helminth derived molecules, Immune regulation, Mite-allergic asthma

中图分类号:

R383

李文杰, 冯萌, 程训佳. 蠕虫及其来源分子对螨性哮喘免疫调控的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(2): 131-136.

LI Wenjie, FENG Meng, CHENG Xunjia. Research advances of the immune regulation of helminths and their derived molecules on mite-induced asthma[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2023, 41(2): 131-136.

图/表 1

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