中国寄生虫学与寄生虫病杂志 ›› 2021, Vol. 39 ›› Issue (6): 719-724.doi: 10.12140/j.issn.1000-7423.2021.06.001
收稿日期:
2021-10-28
修回日期:
2021-11-17
出版日期:
2021-12-30
发布日期:
2021-12-05
通讯作者:
江陆斌
作者简介:
石明丽(1992-),女,博士研究生,从事恶性疟原虫var基因的转录调控研究。E-mail: smlgod@163.com
基金资助:
SHI Ming-li(), XIAO Bo, JIANG Lu-bin*()
Received:
2021-10-28
Revised:
2021-11-17
Online:
2021-12-30
Published:
2021-12-05
Contact:
JIANG Lu-bin
Supported by:
摘要:
疟疾是由疟原虫感染引起的传染性疾病。var基因编码的红细胞膜表面蛋白1(PfEMP1)是恶性疟原虫致病过程中最主要的毒力因子,与疟原虫感染红细胞的抗原变异及细胞黏附过程密切相关。var基因表达受严格的时空调控,一般来说,单个疟原虫在红内期只表达一个var基因,遵循相互排斥的表达策略。本文综述了恶性疟原虫var基因调控的研究进展以加深人们对疟疾致病机制的理解。
中图分类号:
石明丽, 肖波, 江陆斌. 恶性疟原虫var基因的表达调控机制研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(6): 719-724.
SHI Ming-li, XIAO Bo, JIANG Lu-bin. Research progress on the expression regulation of var genes in Plasmodium falciparum[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2021, 39(6): 719-724.
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