中国寄生虫学与寄生虫病杂志 ›› 2021, Vol. 39 ›› Issue (6): 719-724.doi: 10.12140/j.issn.1000-7423.2021.06.001

• 特约综述 • 上一篇    下一篇

恶性疟原虫var基因的表达调控机制研究进展

石明丽(), 肖波, 江陆斌*()   

  1. 中国科学院分子病毒与免疫重点实验室,中国科学院上海巴斯德研究所,上海 200031
  • 收稿日期:2021-10-28 修回日期:2021-11-17 出版日期:2021-12-30 发布日期:2021-12-05
  • 通讯作者: 江陆斌
  • 作者简介:石明丽(1992-),女,博士研究生,从事恶性疟原虫var基因的转录调控研究。E-mail: smlgod@163.com
  • 基金资助:
    国家自然科学基金(31771455);国家自然科学基金(31900428)

Research progress on the expression regulation of var genes in Plasmodium falciparum

SHI Ming-li(), XIAO Bo, JIANG Lu-bin*()   

  1. CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China
  • Received:2021-10-28 Revised:2021-11-17 Online:2021-12-30 Published:2021-12-05
  • Contact: JIANG Lu-bin
  • Supported by:
    National Natural Science Foundation of China(31771455);National Natural Science Foundation of China(31900428)

摘要:

疟疾是由疟原虫感染引起的传染性疾病。var基因编码的红细胞膜表面蛋白1(PfEMP1)是恶性疟原虫致病过程中最主要的毒力因子,与疟原虫感染红细胞的抗原变异及细胞黏附过程密切相关。var基因表达受严格的时空调控,一般来说,单个疟原虫在红内期只表达一个var基因,遵循相互排斥的表达策略。本文综述了恶性疟原虫var基因调控的研究进展以加深人们对疟疾致病机制的理解。

关键词: 恶性疟原虫, 毒力因子, var基因, 表达调控, 表观修饰

Abstract:

Malaria is an infectious disease caused by Plasmodium infection. The erythrocyte membrane surface protein 1 (PfEMP1) encoded by the var gene family is the key virulence factor in the pathogenic process of P. falciparum, which is closely related with the antigen variation and cytoadhesion. The expression of var genes is strictly controlled by time and space. Generally, a single Plasmodium parasite expresses only one var gene in the erythrocytic stage, following a mutually exclusive expression strategy. Based upon current researches, we make a comprehensive summary on var gene expression regulation mechanism to improve the understanding of the pathogenesis of malaria.

Key words: Plasmodium falciparum, Virulence factor, var genes, Expression regulation, Epigenetic modification

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