自然杀伤T细胞在寄生虫感染免疫中作用的研究进展

doi:10.12140/j.issn.1000-7423.2020.04.014

中国寄生虫学与寄生虫病杂志 ›› 2020, Vol. 38 ›› Issue (4): 477-481.doi: 10.12140/j.issn.1000-7423.2020.04.014

自然杀伤T细胞在寄生虫感染免疫中作用的研究进展

刘毅¹^,²(), 蔡玉春², 陈韶红², 陈家旭²^,^*()

1 上海健康医学院医学技术学院,上海201318
2 中国疾病预防控制中心寄生虫病预防控制所,国家热带病研究中心,世界卫生组织热带病合作中心,科技部国家级热带病国际联合中心,卫生部寄生虫病原与媒介生物学重点实验室,上海200025

收稿日期:2019-10-22 出版日期:2020-08-30 发布日期:2020-09-09
通讯作者: 陈家旭
作者简介:刘毅（1981-）,男,讲师,博士研究生,从事寄生虫感染免疫研究。E-mail：liuy_52@sumhs.edu.cn
基金资助:
2019年上海健康医学院师资人才百人库项目(B1-0200-19-311143)

Advances in research on the roles of natural killer T cells in immune responses to parasitic infections

LIU Yi¹^,²(), CAI Yu-chun², CHEN Shao-hong², CHEN Jia-xu²^,^*()

1 Shanghai University of Medicine and Health Sciences, College of Medical Technology, Shanghai 201318, China
2 National Institute of Parasitic Diseases, Chinese Center for Diseases Control and Prevention; Chinese Center for Tropical Diseases Research; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; Key Laboratory of Parasite and Vector Biology, Ministry of Public Health, Shanghai 200025, China

Received:2019-10-22 Online:2020-08-30 Published:2020-09-09
Contact: CHEN Jia-xu
Supported by:
Hundred Talents Project of Shanghai University of Medicine & Health Sciences in 2019(B1-0200-19-311143)

摘要/Abstract

摘要：

自然杀伤T（NKT）细胞是一种同时具有T细胞与NK细胞表面标志的固有免疫细胞。NKT细胞活化后分泌的细胞因子具有影响适应性免疫的性质,是联系固有免疫和适应性免疫的桥梁之一,参与抗感染、肿瘤免疫、自身免疫病等过程。NKT细胞在寄生虫感染的免疫过程中也发挥着承接固有免疫与适应性免疫的重要作用,但目前对该领域的研究相对较少。本文主要对NKT细胞在利什曼原虫、疟原虫、锥虫和血吸虫感染免疫中作用的研究进展进行综述。

关键词: 寄生虫感染, 自然杀伤T细胞, 免疫

Abstract:

Natural killer T(NKT) cells are a type of innate immune cells that express both T cell and NK cell surface markers. The cytokines secreted by NKT cells upon activation possess some properties that affect the adaptive immunity, thus bridging innate and adaptive immunity and playing important roles in anti-infection processes, tumor immunity and autoimmune diseases. NKT cells also play an important role in bridging innate and adaptive immunity during immune responses to parasitic infections. However, little research has been conducted in this field. In this article, the roles of NKT cells in immune responses to Leishmania, Plasmodium, Trypanosoma and Schistosoma infections are reviewed.

Key words: Parasite infection, Natural killer T cells, Immunity

中图分类号:

刘毅, 蔡玉春, 陈韶红, 陈家旭. 自然杀伤T细胞在寄生虫感染免疫中作用的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(4): 477-481.

LIU Yi, CAI Yu-chun, CHEN Shao-hong, CHEN Jia-xu. Advances in research on the roles of natural killer T cells in immune responses to parasitic infections[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2020, 38(4): 477-481.

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自然杀伤T细胞在寄生虫感染免疫中作用的研究进展

Advances in research on the roles of natural killer T cells in immune responses to parasitic infections

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