miRNA介导血吸虫和宿主相互作用的研究进展

doi:10.12140/j.issn.1000-7423.2020.03.001

摘要/Abstract

摘要：

血吸虫病是一种严重但被忽视的热带传染病,全世界感染血吸虫的人数超过2亿。了解血吸虫和宿主相互作用的机制是有效控制和最终消除血吸虫病的关键。miRNA是一种内源性的非编码小RNA,主要在转录后调控基因的功能。最近,越来越多的证据表明,miRNA是血吸虫和宿主相互作用的关键调控因子。本文综述了miRNA介导血吸虫和宿主相互作用的研究进展。

关键词: 血吸虫, miRNA, 宿主, 相互作用

Abstract:

Schistosomiasis is a serious but neglected tropical infectious disease, with more than 200 million infected people worldwide. A better understanding of the schistosome-host interactions is the key to effectively controlling and ultimately eliminating this disease. miRNA is an endogenous non-coding small RNA, which acts post-transcriptional regulation of gene functions. Recently, growing evidence indicates that miRNA is a crucial regulator of schistosome-host interactions. In this review, we summarize research advances on miRNA-mediated schistosome-host interactions.

Key words: Schistosome, MiRNA, Host, Interaction

中图分类号:

R383.24

何兴, 潘卫庆. miRNA介导血吸虫和宿主相互作用的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(3): 259-262.

HE Xing, PAN Wei-qing. Research progress on miRNA-mediated schistosome-host interactions[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2020, 38(3): 259-262.

参考文献 31

[1]	Colley DG, Bustinduy AL, Secor WE, et al. Human schistosomiasis[J]. Lancet, 2014,383(9936):2253-2264. doi: 10.1016/S0140-6736(13)61949-2 pmid: 24698483
[2]	Mutapi F, Maizels R, Fenwick A, et al. Human schistosomiasis in the post mass drug administration era[J]. Lancet Infect Dis, 2017,17(2):e42-e48. doi: 10.1016/S1473-3099(16)30475-3 pmid: 27988094
[3]	Merrifield M, Hotez PJ, Beaumier CM, et al. Advancing a vaccine to prevent human schistosomiasis[J]. Vaccine, 2016,34(26):2988-2991. doi: 10.1016/j.vaccine.2016.03.079 pmid: 27036511
[4]	Sun YJ, Li ZQ, Lv FL. Research progress on the immunopathological mechanism of Schistosoma japonicum egg-induced granuloma[J]. Chin J Parasitol Parasit Dis, 2019,37(6):713-717. (in Chinese)
	( 孙钰浚, 李钊琪, 吕芳丽. 日本血吸虫虫卵肉芽肿免疫病理机制研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2019,37(6):713-717.)
[5]	Bartel DP. MicroRNAs: target recognition and regulatory functions[J]. Cell, 2009,136(2):215-233. doi: 10.1016/j.cell.2009.01.002 pmid: 19167326
[6]	Xue XY, Sun J, Zhang QF, et al. Identification and characterization of novel microRNAs from Schistosoma japonicum[J]. PLoS One, 2008,3(12):e4034. doi: 10.1371/journal.pone.0004034 pmid: 19107204
[7]	Wang ZX, Xue XY, Sun J, et al. An “in-depth” description of the small non-coding RNA population of Schistosoma japonicum schistosomulum[J]. PLoS Negl Trop Dis, 2010,4(2):e596. doi: 10.1371/journal.pntd.0000596 pmid: 20161724
[8]	Cai PF, Gobert GN, McManus DP. MicroRNAs in parasitic helminthiases: current status and future perspectives[J]. Trends Parasitol, 2016,32(1):71-86. doi: 10.1016/j.pt.2015.09.003 pmid: 26489492
[9]	Cai PF, Hou N, Piao XY, et al. Profiles of small non-coding RNAs in Schistosoma japonicum during development[J]. PLoS Negl Trop Dis, 2011,5(8):e1256. doi: 10.1371/journal.pntd.0001256
[10]	Zhu LH, Zhao JP, Wang JB, et al. MicroRNAs are involved in the regulation of ovary development in the pathogenic blood fluke Schistosoma japonicum[J]. PLoS Pathog, 2016,12(2):e1005423. doi: 10.1371/journal.ppat.1005423 pmid: 26871705
[11]	He X, Xie J, Zhang DM, et al. Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways[J]. Hepatology, 2015,61(6):2008-2017. doi: 10.1002/hep.27671 pmid: 25546547
[12]	He X, Sun Y, Lei NH, et al. MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor[J]. Proc Natl Acad Sci USA, 2018,115(1):180-185. doi: 10.1073/pnas.1715965115 pmid: 29255036
[13]	He X, Xie J, Wang YG, et al. Down-regulation of microRNA-203-3p initiates type 2 pathology during schistosome infection via elevation of interleukin-33[J]. PLoS Pathog, 2018,14(3):e1006957. doi: 10.1371/journal.ppat.1006957 pmid: 29554131
[14]	Han HX, Peng JB, Hong Y, et al. MicroRNA expression profile in different tissues of BALB/c mice in the early phase of Schistosoma japonicum infection[J]. Mol Biochem Parasitol, 2013,188(1):1-9. doi: 10.1016/j.molbiopara.2013.02.001 pmid: 23415751
[15]	Cai PF, Piao XY, Liu S, et al. MicroRNA-gene expression network in murine liver during Schistosoma japonicum infection[J]. PLoS One, 2013,8(6):e67037. doi: 10.1371/journal.pone.0067037 pmid: 23825609
[16]	Han HX, Peng JB, Hong Y, et al. Comparison of the differential expression miRNAs in Wistar rats before and 10 days after S. japonicum infection[J]. Parasit Vectors, 2013,6:120. doi: 10.1186/1756-3305-6-120 pmid: 23617945
[17]	Liu X, Qi YF, Yu YR. Effects of soluble egg antigens on hepatic stellate cells in the progression of schistosomiasis-associated liver fibrosis[J]. Chin J Parasitol Parasit Dis, 2019,37(2):218-222. (in Chinese)
	( 刘欣, 齐永芬, 鱼艳荣. 血吸虫病肝纤维化中可溶性虫卵抗原对肝星状细胞的作用[J]. 中国寄生虫学与寄生虫病杂志, 2019,37(2):218-222.)
[18]	Sun Y, Zheng KY, He X, et al. The phenotype changes of Kupffer cells in the progression of hepatic schistosomiasis japonica[J]. Chin J Parasitol Parasit Dis, 2017,35(3):224-229. (in Chinese)
	( 孙悦, 郑葵阳, 何兴, 等. 库普弗细胞在小鼠日本血吸虫肝病发展过程中的表型变化[J]. 中国寄生虫学与寄生虫病杂志, 2017,35(3):224-229.)
[19]	Xu FY, Liu CW, Zhou DD, et al. TGF-β/SMAD pathway and its regulation in hepatic fibrosis[J]. J Histochem Cytochem, 2016,64(3):157-167. doi: 10.1369/0022155415627681 pmid: 26747705
[20]	Ding N, Yu RT, Subramaniam N, et al. A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response[J]. Cell, 2013,153(3):601-613. pmid: 23622244
[21]	He X, Tang R, Sun Y, et al. MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis[J]. EBioMedicine, 2016,13:339-347. doi: 10.1016/j.ebiom.2016.10.024 pmid: 27780686
[22]	Zhu DD, He X, Duan YN, et al. Expression of microRNA-454 in TGF-β1-stimulated hepatic stellate cells and in mouse livers infected with Schistosoma japonicum[J]. Parasit Vectors, 2014,7:148. doi: 10.1186/1756-3305-7-148 pmid: 24685242
[23]	Chen X, Ba Y, Ma LJ, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases[J]. Cell Res, 2008,18(10):997-1006. doi: 10.1038/cr.2008.282 pmid: 18766170
[24]	Valadi H, Ekström K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J]. Nat Cell Biol, 2007,9(6):654-659. doi: 10.1038/ncb1596 pmid: 17486113
[25]	Sarkies P, Miska EA. Molecular biology. Is there social RNA?[J]. Science, 2013,341(6145):467-468. doi: 10.1126/science.1243175 pmid: 23908213
[26]	Wang YG, Fan XB, Lei NH, et al. A microRNA derived from Schistosoma japonicum promotes schistosomiasis hepatic fibrosis by targeting host secreted frizzled-related protein 1[J]. Front Cell Infect Microbiol, 2020,10:101. pmid: 32232014
[27]	He X, Wang YG, Fan XB, et al. A schistosome miRNA promotes host hepatic fibrosis by targeting transforming growth factor beta receptor Ⅲ[J]. J Hepatol, 2020,72(3):519-527. doi: 10.1016/j.jhep.2019.10.029 pmid: 31738999
[28]	Liu JT, Zhu LH, Wang JB, et al. Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism[J]. PLoS Pathog, 2019,15(6):e1007817. doi: 10.1371/journal.ppat.1007817 pmid: 31163079
[29]	Meningher T, Barsheshet Y, Ofir-Birin Y, et al. Schistosomal extracellular vesicle-enclosed miRNAs modulate host T helper cell differentiation[J]. EMBO Rep, 2020,21(1):e47882. doi: 10.15252/embr.201947882 pmid: 31825165
[30]	LaMonte G, Philip N, Reardon J, et al. Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance[J]. Cell Host Microbe, 2012,12(2):187-199. doi: 10.1016/j.chom.2012.06.007
[31]	Winston WM, Molodowitch C, Hunter CP. Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1[J]. Science, 2002,295(5564):2456-2459. doi: 10.1126/science.1068836 pmid: 11834782