中国寄生虫学与寄生虫病杂志 ›› 2020, Vol. 38 ›› Issue (1): 115-119.doi: 10.12140/j.issn.1000-7423.2020.01.017

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金属纳米粒子在常见感染性疾病检测及治疗中的应用研究进展

季亚楠, 廉晓丽, 朱逢龙, 杨毅梅*   

  1. 大理大学基础医学院寄生虫学教研室
  • 收稿日期:2019-04-30 出版日期:2020-02-28 发布日期:2020-03-19
  • 通讯作者: 杨毅梅,E-mail: yimeidali@163.com
  • 作者简介:季亚楠(1993-),女,硕士研究生,从事病原生物学研究。E-mail: yanan_4115@163.com
  • 基金资助:
    国家自然科学基金项目(No. 81460316)

Current applications of metal nanoparticles in detection and treatment of common infectious diseases

JI Ya-nan, LIAN Xiao-li, ZHU Feng-long, YANG Yi-mei*   

  1. Department of Parasitology, School of Basic Medical Sciences, Dali University, Dali 671000, China
  • Received:2019-04-30 Online:2020-02-28 Published:2020-03-19
  • Contact: E-mail: yimeidali@163.com
  • Supported by:
    Supported by the National Natural Science Foundation of China (No. 81460316)

摘要: 近年来,纳米技术发展迅速,金属纳米粒子由于其独特的理化性质,在医学领域中有着良好的发展前景并被逐步推广应用。金属纳米粒子在常见感染性疾病的检测和治疗方面较传统方法有较大的优势。本文介绍了基于纳米金的免疫标记技术在病原体检测方面的应用,主要涉及免疫层析技术、生物传感器的制备和探针技术等,以及纳米金和纳米银在抗感染治疗方面的最新研究进展。

关键词: 金属纳米粒子, 纳米金, 纳米银, 感染性疾病, 检测, 治疗

Abstract: With the rapid development of nanotechnology in recent years, metal nanoparticles have shown promising future in application in medicine, and being gradually popularized due to their unique physicochemical properties. They are advantageous over traditional methods in detection and treatment of common infectious diseases. This review introduces applications of nanogold-based immunolabeling technology in pathogen detection, mainly involving in immunochromatography, biosensor preparation, and probe technology, as well as updated research advances in application of nanogold and nanosilver in anti-infection treatment.

Key words: Metal nanoparticles, Nanogold, Nanosilver, Infectious diseases, Detection, Treatment

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