日本血吸虫虫卵肉芽肿免疫病理机制研究进展

doi:10.12140/j.issn.1000-7423.2019.06.018

中国寄生虫学与寄生虫病杂志 ›› 2019, Vol. 37 ›› Issue (6): 713-717.doi: 10.12140/j.issn.1000-7423.2019.06.018

日本血吸虫虫卵肉芽肿免疫病理机制研究进展

孙钰浚¹(), 李钊琪¹, 吕芳丽^2,^3,^4,^*()

1中山大学中山医学院2015级临床医学（八年制）,广州 510080
2 中山大学中山医学院寄生虫学教研室,广州 510080
3 热带病防治研究教育部重点实验室（中山大学）,广州 510080
4 广东省媒介生物防控工程技术研究中心,广州 510080

收稿日期:2019-06-30 出版日期:2019-12-30 发布日期:2019-12-31
通讯作者: 吕芳丽
作者简介:
作者简介：孙钰浚（1997-）,男,本科生,从事日本血吸虫的免疫病理机制研究。E-mail: sunyj26@126.com
基金资助:
国家自然科学基金（No. 81971955）;中山大学中山医学院2018年本科教学改革与质量工程建设项目;中山大学研究生院2019年重点发展项目（No. cxjh201908）

Research progress on the immunopathological mechanism of Schistosoma japonicum egg-induced granuloma

Yu-jun SUN¹(), Zhao-qi LI¹, Fang-li LV^2,^3,^4,^*()

1 Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
2 Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
3 Key Laboratory of Tropical Disease Control of Ministry of Education, Sun Yat-sen University, Guangzhou 510080, China
4 Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou 510080, China

Received:2019-06-30 Online:2019-12-30 Published:2019-12-31
Contact: Fang-li LV
Supported by:
Supported by the National Natural Science Foundation of China (No. 81971955),the Undergraduate Teaching Reform Project of Zhongshan School of Medicine, Sun Yat-sen in 2018, the Key Development Project of Graduate School, Sun Yat-sen in 2019(No. cxjh201908)

摘要/Abstract

摘要：

宿主感染日本血吸虫后,虫卵可沉积于宿主的肝脏和肠壁等组织,引起Th2型为主的免疫应答,导致虫卵肉芽肿的形成和纤维化。该过程涉及多种类型的细胞参与,如中性粒细胞、巨噬细胞、嗜酸粒细胞、自然杀伤细胞、B细胞（包括调节性B细胞）、T细胞[包括辅助性T细胞（Th）1、2和17等细胞亚型]、调节性T细胞、肝星状细胞和肝细胞等。本文综述了参与日本血吸虫虫卵肉芽肿免疫反应的细胞类型及其可能的作用机制,以期为相关工作者提供参考。

关键词: 日本血吸虫, 虫卵肉芽肿, 免疫反应, 病理机制

Abstract:

After infection with Schistosoma japonicum, mature female adult worms lay eggs which deposit in the liver, intestinal wall, and other tissues of the infected mammalian host, which induces predominant Th2 immune responses and causes egg granuloma and fibrosis. It has been reported that neutrophils, macrophages, eosinophils, natural killer cells, B cells (including regulatory B cells), T cells (including Th1, Th2, and Th17 cells), Treg cells, hepatic stellate cells, and hepatocytes are involved in this process. In this paper, we reviewed the cell types involved in the egg granulomatous response of S. japonicum and their possible mechanisms in order to provide a helpful reference for related researchers in this field.

Key words: Schistosoma japonicum, Egg granuloma, Immune response, Pathological mechanism

中图分类号:

R383.24

孙钰浚, 李钊琪, 吕芳丽. 日本血吸虫虫卵肉芽肿免疫病理机制研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(6): 713-717.

Yu-jun SUN, Zhao-qi LI, Fang-li LV. Research progress on the immunopathological mechanism of Schistosoma japonicum egg-induced granuloma[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2019, 37(6): 713-717.

图/表 1

参考文献 48

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日本血吸虫虫卵肉芽肿免疫病理机制研究进展

Research progress on the immunopathological mechanism of Schistosoma japonicum egg-induced granuloma

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