血吸虫病肝纤维化中可溶性虫卵抗原对肝星状细胞的作用

doi:10.12140/j.issn.1000-7423.2019.02.018

摘要/Abstract

摘要：

血吸虫病是呈世界性流行的人兽共患寄生虫病,其中以埃及血吸虫、曼氏血吸虫和日本血吸虫所引起的疾病流行最广、危害最大,在我国仅有日本血吸虫病流行。血吸虫虫卵沉积于肝脏,虫卵内毛蚴分泌的可溶性虫卵抗原可引起宿主免疫反应,形成虫卵肉芽肿,进而发展为肝纤维化。肝星状细胞的活化是肝纤维化的中心环节,可溶性虫卵抗原对肝星状细胞的调节作用在疾病的进程及发展中起到了重要作用。本文对血吸虫病肝纤维化中,可溶性虫卵抗原对肝星状细胞的调节作用进行综述。

关键词: 血吸虫病, 肝纤维化, 可溶性虫卵抗原, 肝星状细胞

Abstract:

Schistosomiasis is a zoonotic parasitic disease worldwide caused by the infections of Schistosoma haematobium, S. mansoni and S. japonicum. The schistosomiasis endemic in China is only caused by S. japonicum infection that results in the deposition of eggs in the liver and causes the egg granuloma and eventually the liver fibrosis. The soluble egg antigens secreted by the miracidium induce host strong immune responses that contribute to the egg granuloma and liver fibrosis. Hepatic stellate cells are the central part of liver fibrosis. The regulation of soluble egg antigens on hepatic stellate cells plays important roles in the development of the fibrosis. This article reviews the research progress in the roles of soluble egg antigens on hepatic stellate cells in the progression of schistosomiasis-associated liver fibrosis.

Key words: Schistosomiasis, Hepatic fibrosis, Soluble egg antigen, Hepatic stellate cell

中图分类号:

R532.21

刘欣, 齐永芬, 鱼艳荣. 血吸虫病肝纤维化中可溶性虫卵抗原对肝星状细胞的作用[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(2): 218-222.

Xin LIU, Yong-fen QI, Yan-rong YU. Effects of soluble egg antigens on hepatic stellate cells in the progression of schistosomiasis-associated liver fibrosis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2019, 37(2): 218-222.

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